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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C21H22N2O5S
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RX_link
http://www.rxlist.com/cgi/generic3/nafcillin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
414.476 g/mol
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Melting Point
No information avaliable
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H2O Solubility
Soluble
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State
Solid
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LogP
3.373
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Dosage Forms
Powder for solution
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Indication
For the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drugs.
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Pharmacology
Nafcillin is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid. The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus aureus. The penicillinase- resistant penicillins are active in vitro against a variety of other bacteria.
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Absorption
No information avaliable
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side effects and Toxicity
Serious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
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Patient Information
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Organisms Affected
Enteric bacteria and other eubacteria